New variochelins from soil-isolated Variovorax sp. H002

• Jabal Rahmat Haedar,
• Aya Yoshimura and
• Toshiyuki Wakimoto

Beilstein J. Org. Chem. 2024, 20, 692–700, doi:10.3762/bjoc.20.63

• aspartate residue as a query, Nett et al. performed genome mining of photoreactive siderophores and isolated two such siderophores, variochelins A and B, from the soil bacterium Variovorax boronicumulans [5]. The Variovorax spp. belonging to plant growth-promoting rhizobacteria (PGPR) enhance plant

A myo-inositol dehydrogenase involved in aminocyclitol biosynthesis of hygromycin A

• Michael O. Akintubosun and
• Melanie A. Higgins

Beilstein J. Org. Chem. 2024, 20, 589–596, doi:10.3762/bjoc.20.51

• was discovered in the 1950s and is produced by the soil bacterium Streptomyces hygroscopicus [1]. It has broad spectrum antibiotic activity, antitreponemal activity against the pathogen that causes swine dysentery, and selective activity against the spirochete that causes Lyme disease [1][2][3]. It

Secondary metabolites of Bacillus subtilis impact the assembly of soil-derived semisynthetic bacterial communities

• Heiko T. Kiesewalter,
• Carlos N. Lozano-Andrade,
• Mikael L. Strube and
• Ákos T. Kovács

Beilstein J. Org. Chem. 2020, 16, 2983–2998, doi:10.3762/bjoc.16.248

• neighbouring organisms induce and increase the SM production in the tested strains. Bacillus subtilis is a well-studied soil bacterium and is used as a model organism for biofilm formation and sporulation [30]. It has been shown that several members of the B. subtilis species complex have exceptional plant

4-Hydroxy-3-methyl-2(1H)-quinolone, originally discovered from a Brassicaceae plant, produced by a soil bacterium of the genus Burkholderia sp.: determination of a preferred tautomer and antioxidant activity

• Dandan Li,
• Naoya Oku,
• Yukiko Shinozaki,
• Yoichi Kurokawa and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 1489–1494, doi:10.3762/bjoc.16.124

• in the host organisms. Keywords: antioxidant; Burkholderia sp; quinolone; soil bacterium; Zn2+ enrichment culture; Findings 4-Hydroxy-2(1H)-quinolone (3) is a unique structural motif mostly found in alkaloids from rutaceous plants (family Rutaceae) [1][2]. This motif has several tautomeric forms

Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

• Ronja Driller,
• Daniel Garbe,
• Norbert Mehlmer,
• Monika Fuchs,
• Keren Raz,
• Dan Thomas Major,
• Thomas Brück and
• Bernhard Loll

Beilstein J. Org. Chem. 2019, 15, 2355–2368, doi:10.3762/bjoc.15.228

• , Technical University of Munich (TUM), Lichtenbergstr. 4, 85748 Garching, Germany Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel 10.3762/bjoc.15.228 Abstract CotB2 catalyzes the first committed step in cyclooctatin biosynthesis of the soil bacterium Streptomyces melanosporofaciens. To

• cyclooctatin biosynthetic gene cluster in particular the TPS CotB2 from the soil bacterium Streptomyces melanosporofaciens MI614-43F2 (Figure 1) [31]. Cyclooctatin 5, with its distinct 5–8–5 ring motif, belongs to the fusicoccane diterpenoids that encompass a wide range of bioactivities, such as bacteriostatic

• industrial application. Within the subsequent paragraphs, we would like to summarize the current understanding of the unusual reaction mechanism and the biotechnological applications. Review The cyclooctatin biosynthetic gene cluster The cyclooctatin gene cluster from the soil bacterium S. melanosporofaciens

Stereochemical investigations on the biosynthesis of achiral (Z)-γ-bisabolene in Cryptosporangium arvum

• Jan Rinkel and
• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2019, 15, 789–794, doi:10.3762/bjoc.15.75

• in the biosynthesis of the achiral sesquiterpene (Z)-γ-bisabolene (5) by a TS from a soil bacterium. Results and Discussion Functional characterisation of a bacterial (Z)-γ-bisabolene synthase Within our efforts to characterise bacterial TSs with new functions and mechanisms, a TS (WP_035857999) from

Activation of cryptic metabolite production through gene disruption: Dimethyl furan-2,4-dicarboxylate produced by Streptomyces sahachiroi

• Dinesh Simkhada,
• Huitu Zhang,
• Shogo Mori,
• Howard Williams and
• Coran M. H. Watanabe

Beilstein J. Org. Chem. 2013, 9, 1768–1773, doi:10.3762/bjoc.9.205

• , dimethyl furan-2,4-dicarboxylate. The cryptic metabolite represents the first non-azinomycin related compound to be isolated and characterized from the soil bacterium, S. sahachiroi. The results from this study suggest that abolishing production of otherwise predominant natural products through genetic

Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous

• Elaine O’Reilly,
• Suzanne J. Aitken,
• Gideon Grogan,
• Paul P. Kelly,
• Nicholas J. Turner and
• Sabine L. Flitsch

Beilstein J. Org. Chem. 2012, 8, 496–500, doi:10.3762/bjoc.8.56

• dioxygenases has made them the focus of research into bioremediation and biocatalyst development [12]. The soil bacterium Rhodococcus rhodochrous (also referred to as Corynebacterium sp. 7E1C, Rhodococcus rhodochrous ATCC 19067 and Gordonia rubripertinctus 7E1C) is known to oxidise a wide variety of aliphatic

Mitomycins syntheses: a recent update

• Jean-Christophe Andrez

Beilstein J. Org. Chem. 2009, 5, No. 33, doi:10.3762/bjoc.5.33

• . Discussion 1. Mitomycin isolation and nomenclature Mitomycins are natural products isolated from extracts of genus Streptomyces, a filamentous gram-positive soil bacterium that produces a wide array of biologically active compounds, including over two-thirds of the commercially important natural-product